Federal Rural University of Rio de Janeiro, Seropédica, Brazil

Background: Chronic granulocytic leukemia (CML) is characterised by city (Ph) body. The pH scale detected by karyotyping in ninetieth CML however 5-10% could have variant translocation wherever another body addition to body # nine and twenty two. The aim of gift report is to explain a rare many-sided translocation with seldom describe 8p21 breakpoint. Case report: Retrospective cytogenetical info between March 2104 and February, 2015 was probe for CML cases beside variant translocation. Out of 732 confirmed CML, one male patient with twenty two year age showed a variant translocation as forty six,XY,t(8;9;22) (p21;q34;q11.2). Conclusion: A rare many-sided translocation of body eight, nine and twenty two was detected with cytogenetical and twin visible radiation in place union technique (D-FISH) as novel breakpoint at 8p21 that was earlier reported by Abe et al., (1989) before twenty six years.

Chronic myeloid leukemia; Three way translocation; Breakpoint; Karyotype

Kelipe Machado. In Chronic Myeloid Leukemia, a Rare t (8;9;22)(p21;q34;q11.2) Three Way Philadelphia Variant. Insights Journal of Surgery and Clinical Case Reports 2021.